Amron Corporation's work in behavior modification through verbal messages has been funded by the National Institutes of Health for the last 7 years. The precursor to Hand Hygiene Prompts was installed at a residential unit for Alzheimer's disease patients and at a pediatrician's office. The Small Business Innovative Research (SBIR) Phase I result was that voice prompts increased handwashing compliance significantly.

The subsequent Phase II SBIR study was carried out at Johns Hopkins University Hospital in Baltimore, MD and at Biloxi Specialty Hospital (BSH), in Biloxi, MS. HHP prompted for hand hygiene upon exiting a patient room at JHU and upon entering a patient room at BSH. Baseline hand hygiene compliance was established without prompting in the Pre test phase, compliance in response to voice prompts in the Test phase, and the extent of learned compliance in the Post test phase, where no prompts were delivered. The infection rate was recorded during all three phases.